Optimization of floating bilayered tablets of Ketorolac Tromethamine
نویسندگان
چکیده
منابع مشابه
In-vitro Release Characterization of Ketorolac Tromethamine Loaded Matrix Tablets
The present investigation highlighted the formulation and release characterization of Ketorolac Tromethamine loaded matrix tablet. Various formulations of tablets were prepared by direct compression method along with Kollidon SR and Hydroxy Propyl Methyl Cellulose (HPMC) as release retardant polymers. Each of the formulated tablets contains 50mg Ketorolac Tromethamine. The evaluation involved p...
متن کاملOptimization of In-vitro Permeation Pattern of Ketorolac Tromethamine Transdermal Patches
The present study was undertaken to develop a suitable transdermal matrix patch of ketorolac tromethamine with different proportions of polyvinyl pyrrolidone (PVP) and ethyl cellulose (EC) using a D-optimal mixture design. The prepared transdermal patches were subjected to different physicochemical evaluation. The surface topography of the patches was examined by scanning electron microscopy (S...
متن کاملEffect of Processing and Sintering on Controlled Release Wax Matrix Tablets of Ketorolac Tromethamine
The objective of present study was to evaluate the effect of processing methods and sintering condition on matrix formation and subsequent drug release from wax matrix tablets for controlled release. Ketorolac tromethamine and compritol were processed with appropriate diluent using either dry blending, spray drying, partial melt granulation or melt granulation.The tablets were then sintered at ...
متن کاملBioavailability Studies of Ketorolac Tromethamine Fast Dissolving Tablets Prepared By Direct Compression Method
This study was concerned with the investigation of acute pharmacological responses (pharmacodynamics) including analgesic and anti-inflammatory effects of ketorolac tromethamine fast dissolving tablets prepared by direct compression method using 3% croscarmellose sodium as a superdisintegrant by applying tail flick test and carragenan induced rat paw edema test respectively. Also, the work aime...
متن کاملOcular pharmacokinetics of 0.45% ketorolac tromethamine
PURPOSE A new carboxymethylcellulose (CMC)-containing ophthalmic formulation of 0.45% ketorolac, pH 6.8 (Acuvail(®)) was recently developed for treatment of inflammation and pain after cataract surgery. This study compared pharmacokinetics of the new formulation with that of a prior formulation, 0.4% ketorolac, pH 7.4 (Acular LS(®)). METHODS Ketorolac formulations were administered bilaterall...
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ژورنال
عنوان ژورنال: Pharmaceutical and Biological Evaluations
سال: 2017
ISSN: 2394-0859
DOI: 10.26510/2394-0859.pbe.2017.03